CANONIC Study

About the project

Biological samples from a large prospective observational study, performed within the context of the chronic liver failure (CLIF) Consortium, aimed to develop a definition of Acute-on-Chronic Liver Failure (ACLF) and identify cirrhotic patients with a high risk of short-term mortality.

Principal researcher

Dr. Richard Moreau

Dr. Richard Moreau

Dr. Richard Moreau, Service d’Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy; Inserm U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy (Paris) and Université Paris Diderot-Paris 7, Paris, France.

Collection points

EASL-CLIF centers participating in the CANONIC study:

  • Medical University of Vienna, Austria
  • Medical University of Innsbruck, Austria
  • UniversiteLivre de Bruxelles, Erasme Hospital, Belgium
  • Ghent University, Belgium
  • University Hospital Gasthuisberg, Leuven, Belgium
  • Institute for Clinicaland Experimental Medicine, Prague, Czech republic
  • Hvidovre Hospital, Denmark
  • Aarhus University Hospital, Denmark
  • HôpitalBeaujon, Clichy, France
  • Hôpital Paul Brousse, Villejuif, France
  • University of Bonn, Germany
  • University Hospital Hamburg, Germany
  • University Medical School, Munich, Germany
  • Goethe University Hospital, Frankfurt, Germany
  • StVincent’s University Hospital Dublin, Irelanda
  • Policlinico S OrsolaMalpighi, Bologna, Italy
  • University of Padova, Italy
  • University of Turin, Italy
  • Oslo University Hospital, Norway
  • Hospital Clínic de Barcelona, Spain
  • Hospital de al Santa Creu I Sant Pau, Barcelona, Spain
  • University Hospital of Ramón y Cajal, Madrid, Spain
  • Hospital Vall d'Hebron, Barcelona, Spain
  • Hospital General Universitario Gregorio Marañon. Madrid, Spain
  • Reina Sofia Hospital, Madrid, Spain
  • University of Berne, Switzerland
  • Kings College London, United Kingdom
  • Royal Free Hospital, London, United Kingdom

Collaborating Institutions

  • Laboratorios GrífolsGenoma España

Available samples

    • Plasma: 11.859
    • Serum: 9.046
    • Urine: 6.311
    • Blood for genetics: 859
    • Ascitic fluid: 246
    • Liver biopsy: 8

Cofinanced by: